‘Shaq Vs.’
8 p.m., WLS-Ch. 7
Shaquille O’Neal has few rivals in the basketball world, but how would he fare against other top athletes on their own turf? That’s the premise of this high-spirited new reality series, which finds the NBA player challenging stars in other sports, swimming against Olympic gold medalist Michael Phelps and, in the opener, trying his gridiron skills against Pittsburgh’s Ben Roethlisberger.
‘Nova scienceNOW’
9 p.m., WTTW-Ch. 11
If you have a predisposition to a certain disease, do you want to know? That’s one of the things this new episode gives you to think about, as host Neil deGrasse Tyson looks into personal genetic profiling.
‘The Cleaner’
9 p.m., A&E
A self-help guru turns to William (Benjamin Bratt) for help when her drug-addicted son disappears right before her second book is released. After the team finds him, William learns the young man is also struggling with gender dysphoria.
‘Miami Social’
8 p.m., Bravo
In the season finale, George is concerned about his visiting mother meeting Lina, but not to worry — Lina just blows off dinner with his mother and friends.
‘True Grit’
9:15 p.m., TCM
John Wayne won his only best actor Oscar for his performance in this 1969 Western. His character, Rooster Cogburn, is an aging, hard-drinking U.S. marshal who was one of the West’s best lawmen in his prime. A teenage girl (Kim Darby) enlists his help in finding and taking down the man who killed her father.
‘P.O.V.’
10 p.m., WTTW-Ch. 11
Among the titles in this program of short films are “Utopia, Part 3: The World’s Largest Shopping Mall,” about the South China Mall, which now stands largely empty; “Nutkin’s Last Stand,” about a British effort to help the red squirrel, now under attack from North American gray squirrels; and “34x25x36,” part of Jesse Epstein’s trilogy about body image.
‘Late Show With David Letterman’
10:35 p.m., WBBM-Ch. 2
Real estate mogul Donald Trump; actress Diane Kruger; Billy Currington performs.
‘The Tonight Show With Conan O’Brien’
10:35 p.m., WMAQ-Ch. 5
Sacha Baron Cohen as fashion reporter Bruno; actor Stephen Moyer; Zumanity.
