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-$2.49

11.6%

Shares of Schering-Plough Corp. had the biggest percentage drop in the Standard & Poor’s 500 index, falling to $18.95. Researchers studying Vytorin, the cholesterol drug it sells with Merck & Co., said it failed to reduce the risk of heart valve disease. Merck shares fell 6.2 percent, to $35.33.

$1.46

5.8%

American International Group Inc. shares rose to $26.53. A Bank of America analyst raised his rating on the giant insurer to “buy” from “neutral.”

$6.18

21.6%

Shares of Timken Co. had their biggest percentage gain in more than three decades, soaring to $34.86. The maker of bearings used in cars and tools raised its forecast for 2008 profit and said second-quarter results beat its estimates.

-$3.43

20.3%

Charlotte Russe Holding Inc. shares had their biggest percentage decline since September 2004, tumbling to $13.46. The clothing retailer said third-quarter profit fell as consumers curbed spending.

$3.15

25.3%

Shares of Gibraltar Industries Inc. surged to $15.61. Piper Jaffray Cos. analysts raised their rating on the manufacturer of metal parts for buildings and cars to “buy” from “neutral.”

-$16.82

42%

ArthroCare Corp. shares posted their biggest percentage loss, sinking to $23.21. The maker of surgical tools said it will restate results lower for the past two years and first quarter.