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By Ilaina Jonas

NEW YORK, April 6 (Reuters) – A major shareholders advisory

service on Friday urged holders of U.S. gene sequenci ng company

Illumina to vote against rejected suitor Roche Holdings AG’s

proxy contest to expand Illumina’s board and fill it with its

own nominees.

Institutional Shareholders Services advised Illumina

shareholders to reject proposals from Swiss pharmaceutical giant

Roche, and agreed with Illumina’s board that the Swiss

pharmaceutical’s offer to take over the San Diego-based company

is inadequate.

“Because the revised offer of $51 is not yet demonstrably in

the range of a compelling starting point for negotiation, the

board appears to have acted appropriately in rejecting the Roche

bid,” ISS said in its report.

Last week, Illumina rejected the sweetened offer, raised

from a January offer of $44.50 per share, saying it dramatically

undervalued the company.

Roche responded by launching a tender offer and a proxy

contest to replace four Illumina directors with its own

nominees. It also offered a proposal to expand the board by two

additional seats and fill them with Roche nominees. If Roche is

successful on all these proposals, its nominees would comprise a

majority on the board.

Roche has said its offer is the highest ever for a company

in the sector. Illumina makes equipment that decodes a person’s

entire genome. A combination of the two companies would give

Roche a leading position in the promising market for gene

sequencing and fit snuggly with its large diagnostics business.

ISS said that traditional mergers and acquisition valuation

metrics are inadequate for “a company whose real potential – the

vast end markets, in and beyond heathcare, which are beginning

to turn to its technology – is all before it.”