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* Early trial showed patients gained control over voices

* Patients learn to stand up to tormentors using avatar

* Schizophrenia affects around one in 100 people worldwide

By Kate Kelland

LONDON, May 29 (Reuters) – Psychiatrists are developing a

system that can help people with schizophrenia control and

sometimes silence the tormenting voices in their heads by

confronting a computer avatar of them.

In a pilot study of 16 patients who underwent the British

experimental treatment, known as “avatar therapy”, doctors found

almost all of them reported a reduction in how often they heard

voices and how severe the distress caused by them was.

The first stage in the therapy is for the patient to create

a computer-based avatar by choosing a face and a voice for the

entity they believe is talking to them.

The system then synchronises the avatar’s lips with its

speech, enabling a therapist to speak to the patient through the

avatar in real time. The therapist encourages the patient to

oppose the voice and gradually teaches them to take control of

their hallucinations.

“Even though patients interact with the avatar as though it

was a real person, because they have created it they know that

it cannot harm them, as opposed to the voices, which often

threaten to kill or harm them and their family,” Professor

Julian Leff, who developed the therapy, told reporters.

“The therapy helps patients gain the confidence and courage

to confront the avatar, and their persecutor.”

Schizophrenia is a psychiatric disorder that affects around

one in 100 people worldwide. Its most common symptoms are

delusions and auditory hallucinations, or hearing voices.

Leff said patients often told him the voices were the worst

feature of their condition. “They can’t think properly, they

can’t concentrate, they can’t work and they can’t sustain social

relationships,” the professor of mental health sciences at

University College London told the briefing.

In the pilot study, three of the patients, who until the

trial had been tormented by voices for between 3-1/2 and 16

years, stopped hearing them completely after working with the

avatar system.

Each therapy session was also recorded and given to the

patient on an MP3 player “so that the patient essentially has a

therapist in their pocket which they can listen to at any time

when harassed by the voices”, Leff said.

As a result of the early success, the medical charity The

Wellcome Trust has given Leff’s team 1.3 million pounds ($2

million) to test the therapy in a larger group of patients.

Thomas Craig, a psychiatrist who will lead the larger trial

at King’s College London’s Institute of Psychiatry, said

auditory hallucinations were particularly disturbing for

patients and can be extremely difficult to treat successfully.

“The beauty of the (avatar) therapy is its simplicity and

brevity,” he said. “Most other psychological therapies for these

conditions are costly and take many months to deliver.”

He added that if the larger trial proved successful, avatar

therapy could be widely available within a few years, since the

technology is relatively simple and many mental health

professionals already have the skills needed to deliver it.

(Editing by Alison Williams)