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* 280 cases reported in past week

* 2003 was worst year on record in U.S.

By Marice Richter

DALLAS, Oct 10 (Reuters) – The outbreak of West Nile disease

in the United States moved a step closer on Wednesday to

becoming the second worst on record with federal health

authorities reporting 280 cases of the virus-caused illness over

the past week.

There have now been 4,249 cases of West Nile recorded this

year, according to the Centers for Disease Control and

Prevention, 20 cases fewer than in 2006, the second-largest

outbreak on record.

The number of deaths rose by five to 168 since last week,

the CDC said.

The worst year on record for West Nile disease was 2003,

when 9,862 cases were reported, the CDC said.

The pace of new cases of the disease – which is transmitted

from infected birds to humans by mosquitoes — has slowed since

late summer, authorities said.

More than 70 percent of the cases have been reported in

eight states: Texas, Mississippi, Michigan, South Dakota,

Louisiana, Oklahoma, Illinois and California. Texas has been the

hardest hit, recording close to 40 percent of the cases in the

country, according to the CDC.

The Dallas-Fort Worth area has been the epicenter of this

year’s outbreak, with 33 deaths, according to the Texas

Department of State Health Services.

The Dallas Morning News reported Wednesday that health

officials in Tarrant County, home to Fort Worth, may have vastly

underreported cases of the serious neuroinvasive form of West

Nile.

The report said the number of cases detected through Tarrant

County blood bank screenings – information that helps public

officials determine the size of an outbreak – differs

significantly from what officials there have reported.

But state health officials said it was unlikely cases were

overlooked.

The severe neuroinvasive form of the disease almost always

requires hospitalization and can lead to meningitis,

encephalitis and death, according to the CDC.

“Neuroinvasive disease is not subtle,” said Carrie Williams,

a spokeswoman for the Texas health department. “We’re confident

physicians knew about the outbreak and were on the lookout for

disease.”

Nationwide, half of cases reported to the CDC have been of

the neuroinvasive form. The other half are West Nile Fever, a

milder form which causes flu-like symptoms and is not deadly.

Outbreaks tend to be unpredictable and are typically

triggered by a combination of hot weather and intermittent

rainfall as well as ecological factors such as the size of the

bird and mosquito populations.

(Editing by Corrie MacLaggan, James B. Kelleher and Jim Loney)