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* Third recent case in Georgia, South Carolina

* Doctors unsure what bacteria caused the infection

* Waterborne bacteria blamed for Georgia woman’s infection

(Adds comment, details)

By Harriet McLeod

CHARLESTON, S.C., May 17 (Reuters) – A new mother of twins

in Greenville, South Carolina, is the latest victim of a rare

and potentially fatal flesh-eating bacterial infection, health

officials said on Thursday.

Lana Kuykendall, 36, was in critical but stable condition at

Greenville Memorial Hospital, hospital spokeswoman Sandy Dees

said.

Kuykendall, who gave birth to twins this month at a Georgia

hospital, came home to South Carolina and had severe pain in her

leg, her husband, Darren Kuykendall, told a local television

station. Within 15 minutes of noticing that the painful spot on

her leg was spreading, she went to the hospital, he said.

She underwent her fifth surgery to remove necrotic, or dead,

tissue from her lower leg after being hospitalized last Friday,

the hospital said in a statement.

“A team of surgeons, critical-care physicians and infection

disease specialists at Greenville Memorial Hospital continue to

very closely monitor and treat her condition,” the statement

said.

Kuykendall was diagnosed with necrotizing fasciitis, a

flesh-eating infection that can destroy muscles, skin and

tissue.

Necrotizing fasciitis is typically managed by surgery,

antibiotics and aggressive supportive care, the hospital

said. “She remains very ill but stable,” said Dr. Bill Kelly,

hospital epidemiologist for Greenville Hospital System.

Lana Kuykendall is a paramedic. Her husband, Darren, is a

firefighter.

“We’re extremely grateful for the extraordinary medical care

and the incredible community support we’ve received,” Darren

Kuykendall said.

THE WORST KIND

Dr. Jerry Gibson, an epidemiologist with the South Carolina

Department of Health and Environmental Control said she was on a

ventilator.

“She has the worst kind of bacterial infection,” Gibson told

Reuters. “It destroys tissues and invades the long membranes. We

see four or five cases a year in South Carolina. There’s no

prevention.”

Two other cases of flesh-eating infections have been

reported recently in South Carolina and Georgia. But Gibson

said, “These cases don’t cluster together except randomly.”

Different bacteria can cause necrotizing fasciitis. Gibson

said he had not seen Kuykendall’s medical chart and did not know

what type of bacteria was to blame. The hospital would not name

the underlying bacteria.

Necrotizing fasciitis can be caused by group-A streptococci

or by staphylococci, common bacteria that live on people’s skin

and in their noses, he said.

“Normally, they do nothing,” Gibson said. “Sometimes the

group-A strep causes strep throat. Sometimes the staph causes a

skin infection. Rarely, people can become infected in a place

that’s usually sterile – heart, lung, tissue under the skin –

and have group-A strep where it shouldn’t be.

HIGH MORTALITY RATE

“This is a condition that scares people,” he said. “Patients

are usually very normal and then they deteriorate fast. It

usually starts at the site of a break in the skin. People may

wash it out and it suddenly starts progressing.”

Gibson said he does not know if Kuykendall’s infection could

have started in the hospital where she gave birth.

“It started growing on her leg,” he said.

Necrotizing fasciitis has a high mortality rate. “It moves

so fast and often requires very invasive surgery to correct it,”

he said.

In another recent case, Georgia college student Aimee

Copeland, 24, was being treated for necrotizing fasciitis at

Doctors Hospital in Augusta, Georgia. She has had most of one

leg amputated and was expected to suffer the loss of her fingers

as well.

Copeland contracted the infection after a zip-line accident

in which she fell and cut her leg along the Little Tallapoosa

River near Carrollton, Georgia. Doctors blamed her infection on

the Aeromonas hydrophila bacteria, which are found in fresh or

brackish water.

A former South Carolina fire chief, Glenn Pace, told a local

television station he had been battling the disease since early

April, spent 20 days in the hospital and had three surgeries on

his foot but did not have to have his leg amputated.

The infection is caused by “something subtle, sometimes in a

person who has poor nutrition or alcohol use but also in people

who have no immune deficiencies,” Gibson said.

The “flesh-eating” infection is not communicable, he said.

(Editing by David Adams and Xavier Briand)