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Story line: Colts are on verge of 5th straight AFC South title. They can thank Peyton Manning and instant replay. Manning threw 4 TD passes, 2 after Colts won replay challenges, to take 2-game lead with 4 to go.

Stars: Manning now has 23 TD passes, tying him with Dan Marino as only QBs to throw more than 20 in each of their 1st 10 NFL seasons. … Reggie Wayne had 158 receiving yards, including 48-yard TD. … Jaguars’ Fred Taylor ran for 104 yards, his 2nd straight 100-yard game after having none previously this season.

Extra point: Jaguars’ David Garrard threw his 1st INT in 231 passes this season.

Quote: “In all likelihood, they’ll win the division. They still have to play it out, but they deserve it.”

— Jaguars coach Jack Del Rio.