Last week:
11-5
Against the spread:
6-9-1
Bears (1-0) at Saints (0-1), noon
TV:
WFLD-Ch. 32
Line:
Saints by 7
Over/under:
471/2
Bears were very sharp in opener, particularly on defense, and they’re 3-0 against Sean Payton-coached Saints (although all in Chicago).
Pick:
Bears 27, Saints 24
Cardinals (1-0) at Redskins (1-0), noon
Line:
Redskins by 31/2
Over/under:
441/2
If Cam Newton was able to throw for 400 yards against Cardinals, Rex Grossman is capable of having good game against them. Cardinals’ secondary will be tested again.
Pick:
Redskins 21, Cardinals 20
Raiders (1-0) at Bills (1-0), noon
Line:
Bills by 3
Over/under:
43
Bills stopped run against Chiefs, last season’s No. 1 rushing team. If they can do that against Raiders — a team that lives or dies by the run — they will win.
Pick:
Bills 21, Raiders 17
Packers (1-0) at Panthers (0-1), noon
Line:
Packers by 10
Over/under:
461/2
As well as he played against Cardinals, Cam Newton would have to play even better against defending Super Bowl champions to keep pace with Aaron Rodgers.
Pick:
Packers 35, Panthers 21
Chiefs (0-1) at Lions (1-0), noon
TV:
WBBM-Ch. 2
Line:
Lions by 8
Over/under:
451/2
Chiefs should bounce back after disastrous performance against Bills, but asking them to beat rising Lions on road — without safety Eric Berry — is a lot.
Pick:
Lions 24, Chiefs 17
Browns (0-1) at Colts (0-1), noon
Line:
Browns by 21/2
Over/under:
40
If Kerry Collins can protect ball better than he did vs. Texans, Colts should win. Lockout hurt inexperienced Browns as much as it hurt any NFL team.
Pick:
Colts 18, Browns 15
Bucs (0-1) at Vikings (0-1), noon
Line:
Vikings by 3
Over/under:
411/2
Vikings have some offensive weapons, even if that wasn’t always apparent in opener. Donovan McNabb will rebound from cover-your-eyes debut.
Pick:
Vikings 24, Buccaneers 20
Jaguars (1-0) at Jets (1-0), noon
Line:
Jets by 91/2
Over/under:
39
Maurice Jones-Drew should keep Jets defense honest for while, but Jets have too many ways to score, and Jaguars will find it hard to survive shootout.
Pick:
Jets 30, Jaguars 17
Seahawks (0-1) at Steelers (0-1), noon
Line:
Steelers by 141/2
Over/under:
40
Steelers had seven turnovers in Baltimore and completely collapsed. They are due for big bounce-back, and Seahawks will have hard time keeping things interesting.
Pick:
Steelers 35, Seahawks 13
Ravens (1-0) at Titans (0-1), noon
Line:
Ravens by 6
Over/under:
38
These teams already heading in opposite directions. If Ravens stay focused, there’s no reason they shouldn’t control clock (and Kenny Britt) and win.
Pick:
Ravens 24, Titans 14
Cowboys (0-1) at 49ers (1-0), 3:05 p.m.
Line:
Cowboys by 3
Over/under:
421/2
Cowboys fell apart down stretch against Jets, and 49ers defense is playing well. But Cowboys pass rushers should be able to get to Alex Smith.
Pick:
Cowboys 24, 49ers 17
Bengals (1-0) at Broncos (0-1), 3:15 p.m.
Line:
Broncos by 4
Over/under:
40
Asking Bengals to open with two victories on road is a lot, especially for franchise that hasn’t won in Denver since 1975. Broncos aren’t good, but they’re good enough here.
Pick:
Broncos 21, Bengals 15
Chargers (1-0) at Patriots (1-0), 3:15 p.m.
TV:
WBBM-Ch. 2
Line:
Patriots by 7
Over/under:
531/2
Chargers could surprise here — Philip Rivers played well in injury-riddled AFC title game in Foxborough — but it’s hard to bet against Tom Brady and midseason form.
Pick:
Patriots 30, Chargers 27
Texans (1-0) at Dolphins (0-1), 3:15 p.m.
Line:
Texans by 3
Over/under:
48
Arian Foster should be back, and that will help Texans control tempo. Dolphins are coming off short week after surrendering 622 yards to Patriots.
Pick:
Texans 28, Dolphins 24
Eagles (1-0) at Falcons (0-1), 7:20 p.m.
TV:
WMAQ-Ch. 5
Line:
Eagles by 21/2
Over/under:
491/2
Eagles play home games outside, but they have speed to be great dome team. Michael Vick gets edge in homecoming to Georgia Dome.
Pick:
Eagles 27, Falcons 24
Monday: Rams (0-1) at Giants (0-1), 7:30 p.m.
TV:
ESPN
Line:
Giants by 6
Over/under:
431/2
Even though it appears Sam Bradford will be a go for Rams, that still won’t be enough for a team ravaged by injuries. Eli Manning should hold on at home.
Pick:
Giants 17, Rams 14
